Essay about Toni Morrisons The Bluest Eye - Female...

Female Childhood Icons in Morrisons The Bluest Eye In The Bluest Eye, Toni Morrison weaves stories of violation and hardship to examine the ugliness that racism produces. In this novel, the childhood icons of white culture are negative representations instrumental in engendering internalized racism. For the black child in a racist, white culture, these icons are never innocent. Embodying the ideals of white beauty, they expose the basis for Claudias bewilderment at why she is not attractive and Pecolas desperate desire for beauty. They nourish neither innocent desire, nor the need for acceptance, but denigrate the very idea of blackness. The worship of ideal white beauty, by adults as well as by children, coalesces into a†¦show more content†¦Appearing on screen with male and female, African-American actors, Shirley Temple also symbolizes the directed energy of African-American adults toward the care of white children. Subservient to her needs, and trapped in the stereotyped roles available to them, the adult actors who appe ared as her caretakers often appeared to be childish, rather than childlike, a demeaning position, especially when contrasted with the simulated adult behavior exhibited on screen by Shirley Temple. She keeps them in their place partly by imitating Little Eva, the wise and noble, white child of Uncle Toms Cabin, and partly by her mere presence on screen. As a representation of Little Eva, Shirley Temple characterizes the saintliness of the good child, a saintliness worthy of glorified attention and near worship. If we think of Shirley Temple as Little Eva, then we might also visualize her companions as Uncle Tom or Aunt Chloe, who love their own children, but in embracing the conditions of slavery, willingly put the welfare of white children above their own. On screen, the presence of Shirley Temple as a white child signifies the neglect of the African-American child. For Claudia, Shirley Temple represents her own absence in the attention of her family. Claudia hates Shirley Temple, Not because she was cute, but because she danced with Bojangles, who was my friend, my uncle, my daddy, and whoShow MoreRelatedThe Effects of Scientific Racism on Black Women Essay5776 Words   |  24 PagesBlack adolescent girl who is sexually abused by her stepfather. By writing letters to God and forming supportive relationships with other Black women, Celie finds her own voice, and her voice enables her to transcend the fear and silence of her childhood. By creating Celie and giving her the language to tell of her sexual abuse, Walker adds Celies voice to muted yet growing discussions of the sexual politics of Black womanhood in Black feminist thought. Black feminists have investigated how rape

The Effects Of Social Media On The World Of Technology,...

Wes Williams Mr. Bellissimo ENG-4UI-01 4 November 2015 Desensitizing Society In today’s fast paced world of technology, news and material travel at a supersonic speed. Subjects are then conversed, deliberated as well as disputed feverishly on the virtual landscape: giving way to argument and counter argument, thus leaving no stone unturned. Social media has undeniably played an operative role in sanctioning the common age. Unfortunately though, there is also a flip side. Social media has become a part of our everyday lives, and is a viable tool for learning, communication, and ultimately keeping up to date. What we are not realizing is that we’re becoming desensitized to the real world, we are focused on things that were not even†¦show more content†¦They can carry this out flawlessly without even being known in person. It has created many common problems among teens such as depression, and struggle with confidence on and off social media. I read an article online by The National Council on Crime Prevention reported that in an investigation of young adolescents, 81% said they believe other people cyberbully because they think it’s amusing. They don’t see their victims’ feedbacks in person, cyberbullies may not grasp how much damage they are doing (See Figure #1). Youth also run the risk of involuntarily disclosing their private information since on most occasions; they usually neglect to read carefully websites privacy policies. Whenever young people fail to read the policies and disclaimers, they are exposed to risks of having their personal information disclosed. I can closely relate to this as I tend to not read the instructions, or anything of that nature as I am eager to do whatever I am doing. Social media has desensitized our somewhat balanced understanding of what might happen if I accept this disclaimer, or check the box to accept the terms and agreements. This is exclusively a serious matter in the rising cases of cybercrimes such as identity theft. We have all heard of cyber-attacks, one in particular that stood out to me is the huge wide-spanning cyber espionage operation from Iranian hackers targeting social media platforms in the U.S. I quote, â€Å"Using the fake personas, including

George Berkeley His View Of God Essay Example For Students

George Berkeley: His View Of God Essay As man progressed through the various stages of evolution, it isassumed that at a certain point he began to ponder the world around him. Ofcourse, these first attempts fell short of being scholarly, probablyconsisting of a few grunts and snorts at best. As time passed on, though,these ideas persisted and were eventually tackled by the more intellectual,so-called philosophers. Thus, excavation of the external world began. Asthe authoritarinism of the ancients gave way to the more liberal views ofthe modernists, two main positions concerning epistemology and the natureof the world arose. The first view was exemplified by the empiricists, whostated that all knowledge comes from the senses. In opposition, therationalists maintained that knowledge comes purely from deduction, andthat this knowledge is processed by certain innate schema in the mind. Those that belonged to the empiricist school of thought developed quiteseparate and distinct ideas concerning the nature of the substratum ofsensible objects. John Locke and David Hume upheld the belief thatsensible things were composed of material substance, the basic frameworkfor the materialist position. The main figure who believed that materialsubstance did not exist is George Berkeley. In truth, it is theimmaterialist position that seems the most logical when placed under closescrutiny. The initial groundwork for Berkeleys position is the truism that thematerialist is a skeptic. In the writing of his three dialogues, Berkeleydevelops two characters: Hylas (the materialist) and Philonous (Berkeleyhimself). Philonous draws upon one central supposition of the materialistto formulate his argument of skepticism against him; this idea is that onecan never perceive the real essence of anything. In short, the materialistfeels that the information received through sense experience gives arepresentative picture of the outside world (the representative theory ofperception), and one can not penetrate to the true essece of an object. This makes logical sense, for the only way to perceive this real essencewould be to become the object itself! Although the idea is logical, itdoes contain a certain grounding for agnosticism. Let the reader considerthis: if there is no way to actually sense the true material essence ofanything, and all knowledge in empiricism comes from the senses, then thereal material essence can not be perceived and therefore it can not beposited. This deserves careful consideration, for the materialist has beenself-proclaimed a skeptic! If the believer in this theory were asked if amythical beast such as a cyclops existed he would most certainly say no. Aspart of his reply he might add that because it can not be sensed it is nota piece of knowledge. After being enlightened by the above proposedargument, though, that same materialist is logically forced to agree that,because the material substratum1 itself can not be sensed, its existencecan not be treated as knowledge. The materialist belief has, in effect,become as futile as proving that the cyclops exists; his ideas have leadhim into skepticism. Having proven that the materialist is, at best, a doubter, Berkeleygoes on to offer the compelling argument that primary and secondaryqualities are, together, one thing. As the materialist believes, primaryqualities of an object are those things that are abstract (not senseoriented). Examples of these would be number, figure, motion, andextension. Secondary qualities are those things that are concrete (senseoriented), such as color, smell, sound, and taste. The materialist feelsthat these primary qualities persist even when the secondary ones are notthere. Thus, if a person were blind, then that individual would not beable to hear or to touch items; yet the so-called real qualities such asfigure would remain existent in the objects. As previously shown, thematerialist is agnostic in his belief of these real (primary) qualities. It is here that Berkeley directs an alternate hypothesis: that the abstractprimary qualities dont exist at all. In fact, the immaterialist positionstates that these qualities are merely secondary in nature, as they, too,can not be perceived as being separate from an object. For instance, if aperson is asked to imagine a primary quality alone, as an abstraction, itis impossible. To illustrate this point, suppose that a person is asked tothink simply of number alone. This person may reply that the idea he isformulating is that of three red spheres. In truth this is not an abstractidea, because when the qualities of color (red) and shape (sphere) aretaken away, all that is left is three of nothing! Thus, it is impossibleto think of the abstraction of number, given that an abstract quality cannot focus on anything concrete (such as red spheres in the above mentionedexample). Therefore, it follows that, since no primary, abstract qualitycan exist alone, it is the same as a secondary quali ty in which an actualobject must first be perceived. Berkeley moves on to show that the perceived qualities of an objectare ideas which exist only in a mind. To do this, he states that asensation is an idea. This is logical, for sensations can not be felt bymindless objects. However, it is this point which Berkeley scrutinizes inthe materialist statement that an external object is a material substancewith the sensible qualities inhering in it.2 The materialist isproclaiming that sensible qualities, which exist in the mind only, areactually in the object. Logically, the only possible way for this to occuris if the external object had a mind for the qualities to be thought of andstored by. The notion that inanimate objects have minds is ridiculous, andthus the materialists belief has been reduced to absurdity. Let thereader consider this example to reinforce the point. A ten-story buildingis erected, and a person who lives in a single-story house in the countrysees the new building. To this person the structure may seem quite tall,as he has never seen any building taller than three stories. However, aconstruction worker comes across the same building and perceives its heightquite differently than the previous man. Since the second man usually workson buildings about thirty stories high, he thinks that the building isfairly short. Obviously, the new building can not be both tall and shortat the same time; yet this is the outcome if one believes that the qualityof tallness is inherent in the object. In fact, if the idealist(immaterialist) position is considered it seems logical that one personcould view something differently than another. This is because the ideaconcerning that thing could be different in the two separate minds. Motorcycle EssayOn the other hand, Gods mind is infinite and is thus able to have multipleperceptions. These perceptions of God are also ideas, and it follows thatthese ideas comprise the reality beheld in the finite human mind. Insteadof the materialists belief in the representative theory of perception,where a material object has real (primary) qualities which humans perceiveas sensible (secondary) qualities, Berkeley has posited an alternatetheory. This is that God upholds all of the ideas which comprise humanreality, and people perceive these ideas as sensations directly from Godsinfinite mind. It should also be noted that just as the finite mind is different fromthe infinite mind, the ideas in each mind have some certain distinctions. The finite mind can only contemplate a limited range of thoughts. Toillustrate this, let the reader attempt to imagine an infinite number ofstars. After some intellection, the reader will realize that it is animpossible task. This is because the human mind can only think in terms ofbounded entities; thus, in the above mentioned case, the reader may havethought of a great many stars. However, the stars were finite in number andcould therefore not represent the notion of infinity. In short, the finitemind can only conceive finite thoughts. Not only this, but, as previouslydisgussed, humans can perceive only one thought at a time. If the readerdoes not think this to be the case, then let her attempt to imagine a smallboy and a thunderstorm as completely separate ideas. Although both ideasmay be thought of, the only way for this to occur is when they are placedin the same mental picture. In summary, the human mind has importantlimits which can easily be observed. On the contrary, the infinite mind of God is limitless in its abilityto perceive ideas. In Gods mind, an infinite thought (a thought withoutboundaries) can exist. This infinite ideas existence in Gods mind ismore that possible; it must necessarily be the case. This is becauseinfinite concepts such as the number system and the universe must comefrom, as do all thoughts, a mind. However, since the human mind is finiteand therefore incapable of conceiving boundless thoughts, then thoseinfinite ideas must arise from the infinite mind of God. Not only doesGods mind contain infinite thoughts, but it also must possess the abilityto think of, in the least, many thoughts at once. This is necessarily thecase for the collection of Gods ideas which people call reality to exist;if God did not have this ability then external objects would not exist whenthe finite mind was not perceiving them. Thus far the immaterialist position has been considered in its parts;at this point it shall be viewed as one simple model. Let the readerpicture an isosceles triangle which is divided into three parts: the top,middle, and bottom. At the apex of the figure is Gods infinite mind. Themiddle portion of the triangle is occupied by the finite minds of people. Lastly, the bottom section contains the ideas perceived by humans. BecauseGod is at the pinnacle of the figure, He also perceives the ideas thatpeople do. However, since the human mind is finite, it can not conceive ofthe infinite ideas in Gods mind at the apex of the triangle. Now, theconcepts of either perceiving or being perceived can be added to thepicture. Both the top and middle portions of the figure are minds, so bothof these sections are perceivers. At the bottom of the model are ideas,and since they do not act of their own volition, they are perceived. Aspreviously shown, perceivers are active and the perceived is passive. Lastly, the concept of existence can be applied to the triangle. Sinceexistence is that which is either perceived or perceives5, and each part ofthe model has been shown to meet one of these criteria, then the entiretriangle must be considered to exist. In the final analysis, it is evident that Berkleys immaterialistposition is logically feasible. From his definitions of minds and ideas tohis careful attribution of their respective qualities, George Berkeley hasproduced a compelling argument for his views. However, this is not allthat he has done; in fact, Berkeley has shown the necessary importance ofGod. In the materialist view, a belief in God is not logically necessaryto uphold the material substratum2. Berkeley shows that God must exist,for He is at the heart of Berkeleys position. In short, the materialistview allows for atheism as a possible option. Notes.George Berkeley. Three Dialogues Between Hylas and Philonous.Reason and Responsibility. Ed. Joel Feinberg p. 175. 2.Berkeley, p. 165. 3.Berkeley, p. 165. 4.Berkeley, p. 191. 5.Berkeley, p. 179.

Prohibition The Power Is In The People Essays -

Prohibition: The Power Is In The People The Power is in the People Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the press; or the right of the people peaceably to assemble, and to petition the government for a redress of grievances. (The United States Constitution: The First Amendment). By the action taken on December 12, 1791 (when the Bill of Rights was adopted), the United States of America granted its people a power that would prove extremely potent one-hundred and twenty-nine years later. During the era of Prohibition (1920-1933), people took whatever action necessary to get their way, and did so through the rights afforded to them in the First Amendment. Individuals in favor of Prohibition, seeing the benefits of the institution, worked together to sustain it. Those against Prohibition, feeling a violation of their rights, acted just as intensely, if not even more so, to stop the movement. The government, ignoring the voice of the people, was primarily concerned with keeping Prohibition alive. However, the right to individual voice, a principle upon which the United States was founded, made it impossible for an institution such as Prohibition to exist successfully. In the years prior to and during Prohibition, many people did everything within their power to keep the nation free of alcohol. Numerous committees were formed for the purpose of pursuing the enactment and continuation of Prohibition. Church and religion also played a large part in the fight to keep the nation ?dry?. Some individuals even entered politics and took office in the government in an effort to be heard. People made an united effort to reveal the virtues of Prohibition to the nation. The Anti-Saloon League of America was founded in 1893 at Oberlin, Ohio. Throughout Prohibition, its members went from town to town speaking out against saloons and alcohol (Merz 8). On January 16, 1920, they also declared, ?it is here at last - dry America's first birthday? (Kobler 11). Women established a group of their own as well. In 1874, Protestant women formed the Women's Christian Temperance Union. They, like the Anti-Saloon League of America, cited the advantages of Prohibition (Kobler 10). As a whole, groups such as these utilized their First Amendment rights to the fullest to preach what they believed. God and religion were essential to those fighting to keep Prohibition intact. Reverend Billy Sunday incorporated the issue of Prohibition into many of his sermons. In his most well-known of these sermons Sunday claims: The reign of tears is over. The slums will soon be a memory. We will turn our prisons into factories and our jails into storehouses and corncribs. Men will walk upright now. Women will smile and children will laugh. Hell will be forever for rent (Thornton 8). The Women's Christian Temperance Union held a strong influence in the church scene . They spoke of Prohibition as ?God's present to the nation? (Kobler 11) and sponsored conventions for all who saw Prohibition as a gift from the Father (Kobler 11-13). Some individuals saw entering politics and taking public office as the best way to make a difference in the fight for Prohibition. Senator Morris Sheppard was determined and confident of keeping the nation alcohol free. He believed that with people such as himself in positions of power, the chances of the 18th Amendment (outlawing anything involving alcohol) being repealed were practically non-existent (Merz ix). Obviously, Sheppard's assumption would prove incorrect. The efforts of those against Prohibition were much more radical than the actions of the opposition. Several groups were formed, allowing many to voice their opinions about the evils that existed in the Prohibition laws. The most severe problems resulted from the illegal manufacture of liquor by individuals, and from numerous rebellious acts that brought about more crime. Because of all the negative things that began to occur, many citizens developed a hatred toward the government for instituting Prohibition. The Women's Organization for National Prohibition Reform, The National Association Opposed to Prohibition, The Moderation League, and the American Veterans' Association for the Repeal of the Eighteenth Amendment were just a few of the coalitions that existed during the Prohibition Era which complained about

Californium Facts

Californium Facts Californium is a radioactive rare earth element that can be used as a neutron source. Atomic Number: 98Symbol: CfAtomic Weight: 251.0796Discovery: G.T. Seaborg, S.G. Tompson, A. Ghiorso, K. Street Jr. 1950 (United States)Word Origin: State and University of California Properties: Californium metal has not been produced. Californium (III) is the only ion stable in aqueous solutions. Attempts to reduce or oxidize californium (III) have been unsuccessful. Californium-252 is a very strong neutron emitter. Uses: Californium is an efficient neutron source. It is used in neutron moisture gauges and as a portable neutron source for metal detection. Isotopes: The isotope Cf-249 results from the beta decay of Bk-249. Heavier isotopes of californium are produced by intense neutron irradiation by the reactions. Cf-249, Cf-250, Cf-251, and Cf-252 have been isolated. Sources: Californium was first produced in 1950 by bombarding Cm-242 with 35 MeV helium ions. Electron Configuration [Rn] 7s2Â  5f10 Californium Physical Data Element Classification: Radioactive Rare Earth (Actinide)Density (g/cc): 15.1Melting Point (K): 900Atomic Radius (pm): 295Pauling Negativity Number: 1.3First Ionizing Energy (kJ/mol): (610)Oxidation States: 4, 3 References: Los Alamos National Laboratory (2001), Crescent Chemical Company (2001), Langes Handbook of Chemistry (1952), CRC Handbook of Chemistry Physics (18th Ed.)

Understanding Society Through Cultural Artifacts

Understanding Society Through Cultural Artifacts Researchers can learn a great deal about a society by analyzing cultural artifacts such as newspapers, magazines, television programs, or music. These cultural artifacts, which can also be considered aspects of material culture, can reveal a great deal about the society that produced them. Sociologists call the study of these cultural artifacts content analysis. Researchers who use content analysis are not studying the people, but rather are studying the communications the people produce as a way of creating a picture of their society. Key Takeaways: Content Analysis In content analysis, researchers examine a societys cultural artifacts in order to understand that society.Cultural artifacts are the aspects of material culture produced by a society, such as books, magazines, televisions shows, and movies.Content analysis is limited by the fact that it can only tell us what content a culture has produced, not how members of the society actually feel about those artifacts. Content analysis is frequently used to measure cultural change and to study different aspects of culture. Sociologists also use it as an indirect way to determine how social groups are perceived. For example, they might examine how African Americans are depicted in television shows or how women are depicted in advertisements. Content analysis can uncover evidence of racism and sexism in society. For example, in one study, researchers looked at the representation of female characters in 700 different films. They found that only about 30% of characters with a speaking role were female, which demonstrates a lack of representation of female characters. The study also found that people of color and LGBT individuals were underrepresented in film. In other words, by collecting data from cultural artifacts, researchers were able to determine the extent of the diversity problem in Hollywood. In conducting a content analysis, researchers quantify and analyze the presence, meanings, and relationships of words and concepts within the cultural artifacts they are studying. They then make inferences about the messages within the artifacts and about the culture they are studying. At its most basic, content analysis is a statistical exercise that involves categorizing some aspect of behavior and counting the number of times such behavior occurs. For example, a researcher might count the number of minutes that men and women appear on screen in a television show and make comparisons. This allows us to paint a picture of the patterns of behavior that underlie social interactions portrayed in the media. Strengths of Using Content Analysis Content analysis has several strengths as a research method. First, it is a great method because it is unobtrusive. That is, it has no effect on the person being studied since the cultural artifact has already been produced. Second, it is relatively easy to gain access to the media source or publication the researcher wishes to study. Rather than trying to recruit research participants to fill out questionnaires, the researcher can use cultural artifacts that have already been created. Finally, content analysis can present an objective account of events, themes, and issues that might not be immediately apparent to a reader, viewer, or general consumer. By conducting a quantitative analysis of a large number of cultural artifacts, researchers can uncover patterns that might not be noticeable from looking at only one or two examples of cultural artifacts. Weaknesses of Using Content Analysis Content analysis also has several weaknesses as a research method. First, it is limited in what it can study. Since it is based only on mass communication – either visual, oral, or written – it cannot tell us what people really think about these images or whether they affect people’s behavior. Second, content analysis may not be as objective as it claims since the researcher must select and record data accurately. In some cases, the researcher must make choices about how to interpret or categorize particular forms of behavior and other researchers may interpret it differently. A final weakness of content analysis is that it can be time consuming, as researchers need to sort through large numbers of cultural artifacts in order to draw conclusions. References Andersen, M.L. and Taylor, H.F. (2009). Sociology: The Essentials. Belmont, CA: Thomson Wadsworth.

Madatory labeling In Resturants Essay Example | Topics and Well Written Essays - 250 words

Madatory labeling In Resturants - Essay Example This could be in terms of ingredients that are not fit for their consumption and processes used for production that are not of expected standards. (Elise Golan) The reasons for supporting mandatory labeling of foods have to do with the effects of genetically modified food on the health of individuals. The second reason has to do with the ingredients used in the production of the foods. (IFPRI) Some people may be on certain diets that do not allow them to consume the products. The third reason is basically for the benefit of the manufacturing company such that consumers prefer foods from certain companies because of their reputation, labeling makes them easily identifiable to the consumer. Lastly labeling is important for a country as it helps it in identifying products that come from countries that are known to violate manufacturing standards and therefore they do not allow them in the market to protect its citizens. It also enhances fair competition and market efficiency in a given country. (Elise Golan) Consumer choices may change due to mandatory labeling because they are able to identify products that have been certified as fit for use and those that have not. If for example the product is certified by an international accredited body, chances are consumers will buy it more as compared to another labeled by a local body. Consumer preferences in terms of quality will also make certain products to lose market as a result of these as they will be able to differentiate easily and make choices whether to buy or not. (Elise Golan) Elise Golan, Fred Kuchler, Barry Krissoff. Do Food Labels Make a Difference? . . . Sometimes. Novemeber 2007. 18 Septemeber 2011

Effects of Modern-Day Fascination with Celebrities Essay

Effects of Modern-Day Fascination with Celebrities - Essay Example To be more precise, celebrities make the society to throw away the cultural makeup. Hence, the community members put on a fake image that does not depict their own characters. Technology is the primary cause of these entire obsessions with celebrities. Teens glue themselves to the television; watching programs that makes them more interested in the lives of celebrities more than their own. Smartphones, on the other hand, provide updates about celebrities’ gossips every hour. Just to remember, the past week, everyone talk was all about the revealed story of Solange, Beyonce’s sister attacking Jay-Z while in an elevator (Sarah, 2014). Thus, the society read about it in the magazine, searched it on the internet, or heard it from friends. Most people obsession with celebrities can lead to cultural paradigm alterations. To some extent, the adjustments are real. A good example is of Michael Sam, the footballer who came out building the confidence of most of the young gay athl etes. He advanced the advocacy for gay marriages and promoted free to talk about their sexuality. On its negative side, the culture of celebrities and fascination with status and wealth make the average and poor people feel unworthy of the world. As a result, the mind of the young people growing up to find a place in the world is corrupted with no option but to become rich even through violence. In fact, some researchers claimed the existence of a growing disorder known as â€Å"Celebrity Worship Syndrome.† The disease is however not inclusive of personality disorder (Inglis, 2010).

Negligence of Tort Essay Example for Free

Negligence of Tort Essay DEFINITIONS: In common law jurisdictions, tort is a civil wrong although in certain circumstances it is also treated as a criminal case e.g. in cases of assault. It is recognized legally as a basis for an action of a lawsuit. TORT: In common law jurisdictions, tort is a civil wrong although in certain circumstances it is also treated as a criminal case e.g. in cases of assault. It is recognized legally as a basis for an action of a lawsuit. Torts are considered under the law of obligations. Duties imposed under tort law are considered mandatory for all citizens unlike voluntary obligations imposed under contracts. If a person commits a tortuous act, he/ she are legally a Tortfeasor. Tortiuos acts include breach of duties imposed under statutory laws, causing bodily harm to other people, property, or infringing on another’s legal rights.for there to be a case under tort NEGLIGENCE: This is a legal concept that is usually used to acquire compensation for injuries suffered or accidents met. It is a civil wrong actionable under tort law. Negligence involves behaving in a manner that lacks the legality of protecting other people against foreseeable risks. Under common law for there to be a case under negligence then the following elements must be satisfied. * Duty of care * Breach of the duty EXAMPLES: Experience Of Harm Arising From That Breach. Donoghue V. Stevenson A case of tort on negligence is only successful if the following five elements are met. Firstly, a duty of care must be evident. Donoghue v. Stevenson. Given this fact, we also need to know whether the consequences of  the defendants act were reasonably foreseen. In case of the family friendly fishing company and Neil, they are legally liable for the immediate harm caused to June and Gina. Kent v Griffiths In the case of jack versus the Gosford hospital, jack has no legal case against the hospital since the emergency landing that arose was not reasonably foreseen. Topp v London Country Bus Ltd In addition to this, Gina and June have a legal case against the family friendly fishing company since there was legal proximity of relationship through the contract of hiring the boat. Home Office v Dorset Yacht Club June and Gina have action against Neil and the family friendly fishing. This is because the company and Neil are professionals in this field and yet they breached the duty they are entailed to do. Bolam v Friern Barnet Hospital June has no case against Grosford hospital since the process through which she lost her arm is normal since it does happen. In addition, the hospital done the best it could to help her and thus they cannot be accused of negligence. The Mickey family and the Grosford hospital could all sue the family friendly fishing for damages. However in mitigation the company could claim that there were multiple causes for the injuries suffered, Wilsher v Essex AHA On the issue of Gina and June the company could claim that the presence of the rare fish on the new south Wales coast was not a common thing and thus the fish could be a contributory factor for June and Gina’s accident. On the issue of the Grosford hospital, the family friendly fishing could claim that the helicopter taking an emergency landing could have been a contributory factor to factor to Junes loss of her hand. Jack may have a legally binding case against the Grosford hospital. Although this is, the case jack would end up losing at the end. This is because firstly there was no relationship of proximity either legal or  physical between the incidents that triggered his condition. Caparo v Dickman .In addition, the hospital could claim vicarious liability since at the time of the incident the hospital was on an external mission at the request of the family friendly fishing company. Although Neil is liable for June and Gina’s initial accidents he is well protected by law. Although June and Gina have a case against Neil, Neil could claim protection under the vicarious liability clause. The vicarious liability refers to the notion that a person can and do become responsible or liable for other people’s liabilities because there exist a legally acceptable relationship. Such relationships might include parent-child relationship, or an employer-employee relationship. In this case, the family friendly fishing could be held liable for Neils liabilities since they are the employers. Between the concerned parties, the most liable party is the family friendly fishing company. This is because all the parties concerned in the melee can all sue the family friendly fishing company. This is because the company’s negligent actions are the reason why each involved party is at a loss. The company should prepare itself for lawsuit and the family friendly fishing company should brace itself, to be legally prepared to pay special damages, general damages as well as punitive damages. On top of this, the company should also be prepared for the courts to issue an injunction against them if it is deemed necessary. CONCLUSION: The five elements of negligence should be recognizable under tort law. However, as professor Robertson of Texas University has noted the five elements needs to be kept separate, this is because in practice there arises lots of conceptual mistakes or confusions. The use of vicarious liability as a defense against a case of law on tort of negligence has widely been disputed over its rationale. Many scholars have argued that the use of vicarious liability is only intended to find legally  a more solvent defendant. In a legal perspective, the family friendly fishing company is supposed to pay special and general damages to Gina and June. This is because the company has caused the two irreparable damage because of its own negligent activities. Damages awarded are usually compensatory but not punitive in nature. For the sake of the family friendly fishing company, the damages it would have to pay would most probably include a punitive element. The punitive element would arise if the employee, Neil would declare that indeed he had asked the company to change the boats gear, although the company declined. This refusal of the company to use standard tools for profiteering reasons would be termed as an act of maliciousness or acting in an callously indifferent way.

Pete Sampras Essay -- essays research papers fc

Pete Sampras the American Sensation The reason why I chose to do my research paper on Pete Sampras is because I love to play tennis, and Pete is the greatest tennis player alive. I have always made him my role model, and I hope to one day meet him. I try and model my tennis game after his and it has really helped my tennis game. Pete Sampras is my childhood hero, and that is the reason why I chose the topic of Pete Sampras. Pete was born on August 12, 1971. in Washington, DC. Although Pete was born in Washington, he grew up in Palos Verdes, California. Pete is a direct descendent of Sam and Georgia Sampras. Pete has three Siblings one elder and two younger. The elder sibling is Stella, the current head tennis coach at UCLA. Pete's younger sister Marion has not decided on a career yet, and Pete's third sibling is his only brother, Gus who is the Current Assistant Tournament Director at Scottsdale ATP Tour Event (Role Models). Pete began playing tennis at the age of seven, and when he was nine, his father asked Pete Fischer, a physician and amateur player, to hit with his son. Fischer was so impressed with Pete's ability, he became Pete's personal coach. When Pete was eleven, he had the opportunity to hit with his childhood hero Rod Laver. Pete later told his coach that he was so nervous he couldn't get the ball over the net. Pete rarely won a major junior tournament. Fischer believed that someone of his talent should play up in age groups against older and stronger players to develop his all around game. When Pete reached the age of 14, Fischer changed Pete's two-handed backhand to a one-handed. At the same time of his backhand switch Fischer switched Pete from a safe defensive baseliner to a risky serve and volleyer. The reason he did this was to try and make Pete feel much more laid back and in the end it worked. Pete turned pro at the age of 16 following his junior year in high-school. By the late 1980's, Pete split with his coach Pete Fischer because Pete felt that Fischer was an overbearing perfectionist. After the split with Fischer, Pete picked up a new coach, Tim Gullikson. Tim Gullikson showed Pete the value of playing percentage tennis--going for smart, conservative shots rather than flashy, difficult ones. On May 3, 1996, Gullik... ...aw: 96 R128 Bye, () N/A R64 Kiefer, Nicolas (GER ) 36 6-3 3-6 6-3 R32 Roddick, Andy (USA ) 131 6-7(2) 3-6 (S.L. Price) As you can see Pete has had a few wins but about two years ago, the peak of his career, he wouldn't have lost to any of those players. If you noticed in the Miami Ericsson open he was beat by Andy Roddick a young 19 year old player who just turned pro. That just reinstates my point that he will not be able to keep up with the young up and comers. WORKS CITED 1. " Role Models on the Web: Pete Sampras" April 27, 2000 Available: www.rolemodel.net/Sampras/Sampras.html April 27, 2001 2. Price, S.L. "The Passion of Pete Sampras." Sports Illustrated May 26 1997: 56-63 3. "Pete Sampras." Current Biography. 14th edition. The HW Publishing Company 233-242

Coffee Industry Essay

People usually drink coffee to stay up while awake at night, besides that many people rely on coffee to get their day started. According to the New England Journal of Medicine, â€Å"Drinking coffee can lead to a longer life†; however, many consumers have no idea of the impact of habits on their coffee and coffee farmers around the globe, ethical issues of consumers with the industry is not fair; but to coffee farmers, the issues are human rights violations and use of child labor issues need to be addressed. To remedy this situation, the fair trade will hopefully improve the living conditions of some of the poorest people in the world through certified value and the change in the consumer’s choice. Coffee is one of the most valuable commodities in the world, most of the farmers in the form of small retail and come from developing countries, although the majority of coffee sales are in the America and Europe many people around the world rely on coffee to work and have a better life; however, to producing quality coffee, farmers have to work very hard though farmers receive very little money and the inequity of the coffee producing companies when they sell coffee. Working conditions of farmers in the plantations are very different, although they work hard , but it paid for exploitation, for example , in Guatemala , coffee pickers to harvest 100 pounds to get the minimum wage $ 3 per day (The Problem with Fair Trade Coffee 2010),farmers have to work overtime and do not earn extra money, so farmers use child labor for the production of coffee to save money and use these chemicals effect of the human body in order for a fast development of coffee sale on the market. Moreover, using the chemicals and the development of the coffee industry adversely affect habitat and species decline. In addition, forests are cut down to coffee production affects the environment and soil erosion. According to World Wildlife Fund (WWF), â€Å"converting forest to tea and coffee agriculture can also create erosion and soil loss† (WWF 2010) ; yet the farmers have no choice and/or the opportunity to change. According to the International Coffee Organization or ICO â€Å"Coffee production in 2012 was 144 611 000 bags, mostly from less developed countries such as, Brazil 50 826 000 bags. Vietnam 22 000 000 bags and Indonesia 12 730 000 bags â€Å" (ICO 2013), though coffee production is highly ranked in the world, but farmers still do not get enough money to pay for life, for example, Vietnam in 2012, producing nearly 30 % of world coffee production but the turnover is only 10 % of the total trade value obtained from the global industry, the main reason is due to their ability to improve processing of value and coffee products are limited, coffee roasting plants in countries with rates lower than 10%, when farmers sells 1kg of coffee beans, farmers gets about 2 dollars or an average price of one cup of coffee oversea, yet 1 kg of coffee can make 50 cups. In addition, the links between farmers and enterprises are not strong, the lack of information on farmers markets, so farmers often extorted. Moreover, the risk of crop failure is the fear of the coffee growers. Most of the profits from coffee for export processing enterprises, coffee farmers only enjoy a small percentage. That has caused insecurity for farmers. Solution to this problem is the fair trade. According to Wikimedia, Fair trade coffee is coffee that is certified as having been produced and marketed to a stated set of standards. Many Customers pay a higher price when buying coffee with the certification logo or brand in the Belief Furniture , by doing so, they are helping farmers in the Third World . In particular, the fair trade coffee movement gives a reasonable price to the Farmers who were being a low – wage labor exploitation. However, achieve certification of fair trade, farmers must meet several conditions of production as farmers have to meet a large variety of production standards : there are limits on the use of child labor , pesticides , herbicides , genetically modified products , etc. With these standards met, both consumers and farmers can benefit, with farmers getting the sufficient amount of money for their products, and the consumers getting their product knowing it’s safe to consume and has no effect on the producers financially or ethnically. These farmers must cooperate with businesses to produce the certified products, such amounts received will be higher and the lives of the farmers would be better. In addition, consumers should choose certified products in the supermarket or the market as this will support and will be helpful for farmers. In conclusion, fair trading is the way for farmers and coffee producers to get a higher amount, and will change lives for the better. Therefore farmers should choose fair trade to ensure benefits and consumers should choose products that have been certified to support the farmers. Reference * The problem with Fair Trade Coffee. * Retrieved August 30, 2013, from http://www. ssireview. org/articles/entry/the_problem_with_fair_trade_coffee * Coffee Production and Labor * Retrieved August 30, 2013, from http://www. organicconsumers. org/starbucks/coffeelabor. htm * Fair Trade Coffee * Retrieved August 30, 2013, from http://en. wikipedia. org/wiki/Fair_trade_coffee * International Coffee Organization- EXPORTING COUNTRIES: TOTAL PRODUCTION * Retrieved August 30, 2013, from http://www. ico. org/prices/po. htm * Health and effect of Coffee. * Retrieved August 30, 2013, from http://en. wikipedia. org/wiki/Health_effects_of_coffee * Environmental Impacts of Coffee and Tea Production * Retrieved September 2, 2013 from http://www. hellogreentomorrow. com/blog/2010/11/environmental-impacts-of-coffee-and-tea-production.

Case Study †Motivation Essay

Introduction In this brief introduction, advice for James on how to motivate his Year 5 teachers will be framed by explaining the nature of goal, the dimension of the goal and how it should be set. Secondly, suggestions of the selection of Year 5 teacher will be given. Furthermore, various ways of rewarding the goal achievement will be mentioned while evaluating the role of James during the academic year and the application of goal setting. In addition, unintended consequences of the goal setting methods will be discussed and follow by a conclusion. Nature of goal, Dimension of the goal and how it should be set Refers to Locke (1990 and 1996), goal is an object or aim for an action is the definition of goal and it is something consciously want. Goal can be explained by internal and external factors , goals are thoughts with desired end internally and object or conditions sought externally while a job to be completed is as known as task (Locke 1990 and 1996). In this case, the goal of James is to boost his school average result in NAPLAN test (i.e. the 5 reporting sector ) therefore it is above the national average while the task is to select an appropriate teacher that is able to improve the results of the 5 reporting factors. Dimension of goals can be divided content and intensity and they are not easily separated (Locke 1990). Goal content means the actual object sought and psychological goal that an individual have (Locke 1990 and 1996). Content differs in qualitatively and quantitatively and degree of specificity (Locke 1990). A positive relationship between goal difficulties and performance is founded, the harder the goal is, the better the achievement (Locke 1996). The second factor is intensity. Intensity refers to the depth of the goal, such as scope and integration of the goal setting process and the importance of the goal, etc (Locke1990). Goals can be set according to S.M.A.R.T. which means that goals must be specific, measurable, assignable, realistic and time-related (Rouillard 2003). A specific goal should be details enough to mention what is to be achieved and accomplished, too general statement is insufficient to motive workers (Rouillard 2003).A goal should be measurable which is quantifiable and provide a standard for comparison while indicate whether the goal is reached (Rouillard 2003). Thirdly, an attainable goal should be able to achievable while challenging, a goal with extreme low and  high expectation is insufficient to motivate (Rouillard 2003). Realistic goal means it is practical, possible and achievable (Rouillard 2003). Time-related means to frame the goal with a given period, an out-dated goal has no effect on motivat ion (Rouillard 2003). In this case, James can set a goal like ‘improve 75% of year 5 students results with a grade improvement in the factors of reading, writing, spelling, grammar and punctuation and numeracy within one semester (6 months)’. Access of candidates In this case, the aim is to improve the students’ results therefore teacher effectiveness is the main consideration. Teacher effectiveness is a measure of teacher’s ability to produce an academic growth in a given context and situation (Stronge and Hindman 2006 and Bailey 2006). Various sectors are needed for evaluation. (i) Knowledge/ Teaching certification Richard has the highest degree compare to others and Richard is passionate about upgrading himself to a higher level. Moreover, Richard is familiar with the updated education syllabus as he has completed his bachelor degree few years ago. No specific information about Janice’s educational background is mentioned; it is assumed she has the lowest degree among candidates. Although Janice had attended some teacher training, she is not familiar and active about the updated educational changes and practices which makes her less competitive. Ivar has deep knowledge about psychology and enjoy high degree of reputation and he is a high achieving student which shows Ivar has adequate intelligence level. Refers to Mandeville and Liu cited in Campbell et al (2012), students who are taught by higher levels of teacher certification have better thinking skills and performance than the lower level of knowledge. From the above evaluation, Richard and Ivar are more knowledgeable. (ii) Personal ity Richard is young, enthusiastic, active, ambitious and competitive; Janice is mature, sociable with good personal skills, passionate but less active than Richard and Ivar is logical and rational but not good at communication. Personality is not suggested as a standard for selection as there is no direct relationship between personality and achievement of pupils (Borich cited in Campbell et al 2012 ). More factors should be considered. (iii)  Experience Richard has few years of teaching year 2 and 3 but lack of experience on teaching year 5 and 6; Janice has the most experience among 3 of them and she has 5 years experience on Year 5. Comparing to others, Ivar has the least experience in teaching. Teaching experience is a valuable access however there is no direct relationship between experience and student achievement and teaching experience is only a predictor of student outcomes occasionally (Anderson and Doresett cited in Campbell et al 2012). More factors should be concern. (iv) Self –efficacy ‘A belief in one’s capabilities to organize and execute the course of action required to produce given attainment ‘is called self efficacy (Bandura cited in Campbell et al 2012). Richard and Ivar are very confident about teaching year 5 while Janice is less confident about her skills. It is suggested that students that taught by higher self –efficacy perform better on standardized test and teachers with low self-efficacy have lower expectation of students (Moore and Esselman cited in Campbell et al 2012) . To improve the grade of NAPLAN, advancement of languages and maths are necessary and a teacher with higher self-efficacy is critical as there is positive relationship between self efficacy and the performance of languages and maths of the students (Anderson et al cited in Campbell et al 2012). From the perspective of goal setting theory, an individual with high self efficacy is more willing to set and accept a harder goal while commit to the goals with eff ort (Locke 1996). Richard and Ivar are the better choice. After accessing the above criteria, Richard and Ivar are the better choice since both of them are highly educated and with high self efficacy but Richard is the best choice. Ivar is not specialist in education which shows concern of insufficient knowledge of educational practices while Richard has a better educational knowledge. Refers to Darling-Hammond cited in Campbell et al (2012) , the strongest forecaster of relative achievement compared to others is teacher’s certification therefore Richard will be a better choice based on the element of knowledge. Methods to reward goal achievement The goal cannot be reached by one party’s effort therefore Richard and students should be rewarded. Financial rewards and non-financial rewards are suggested and James should integrate them as a complete reward process in order to work more effectively (Armstrong and Murlis 2007). (i) Financial rewards Merit pay program can be used once Richard reaches the goal. Merit pay is a system that increases the base salary of the employee who achieves the objectives of the business (Snell and Bohlander 2012). James should raise Richard‘s salary with a range of 7 to 9% in order to be motivate (Snell and Bohlander 2012). Financial rewards have no significant in students’ achievement thus financial reward is more appropriate for teachers (Robin 2012). From individual aspect, the increased salary allows Richard to satisfy various needs, such as; help his school fee for his master degree. Richard is competitive, while the financial reward is a tangible form of achievement recognition that satisfies his needs of ego and self- actualization (Armstrong and Murlis 2007). For school, the financial rewards enhance motivation, Richard is more willing to stay in the school and this benefits the school from retaining talents to teach Year 5 students (Armstrong and Murlis 2007). (ii) Non fina ncial rewards Non financial rewards are more effective in motivating (Armstrong and Murlis 2007). James can reward Richard by providing recognition, such as verbally reward with positive feedback, promotion and training and development. James can reward the students by praising the classes and providing extra-circular activities for students to relax and learn. Richard has his own mind in career progression, rewards such as promotion, allows him to reach his individual goal (to have a better career).If Richard is rewarded with training, more knowledge will be received and allow him to have a well preparation for his master degree. Non financial rewards shows recognition which reinforce Richard’s self esteem and self actualization. For the school, non financial rewards bring lasting motivation which maintains Richard’s motivation to work in the school and dedicate more effort for his teaching of Year 5 students. (Armstrong and Murlis 2007) The rewards  motivate the Year 5 students t o study hard in order to get a better result in NAPLAN. James’s role According to managerial competency framework by Quinn, several roles from the framework are selected for James in the application of this case. James is a director, he has to develop a vision and set a clear goal and objectives for his teachers moreover he has to organize and design the whole plan to achieve the goal (Quinn et al 2003). Secondly, James is a mentor, he has to communicate effectively and share his knowledge of NAPLAN with Richard to develop his ability in teaching Year 5 students (Quinn et al 2003). James has to think creatively as he may have to draft new teaching strategies with Richard therefore he has to live and mange the change and his role in this process is innovator (Quinn et al 2003). James is also a co-coordinator, new ideas may suggested by Richard and James has to manage the projects and across the functions to ensure the Richard’s works can run smoothly (Quinn et al 2003).Finally, James is a monitor, performances of students should be reviewed regu larly to keep the process on track while teaching styles should be monitored, for example, James can be a guest teacher in Richard’s class to see how the class runs and provides feedback to Richard (Quinn et al 2003, Mitchell, Ortiz, and Mitchell 1987). Feedback drives performance and motivation therefore feedback should be given frequently, James is able to check the progress of the goal while Richard is able to improve his limitations or retain his advantages (Latham 2007). Unintended consequences  Harder goals drive performance therefore James may set a harder goal for Richard and his year 5 students to achieve (Latham 2007). A harder goal is associated higher risk which may lead to worse performance compare to lower goals, for instance, a harsher teaching style is adopted by Richard but students may face extra pressure and lost their motivation in learning (Latham 2007). Secondly, goal conflicts may happen, such as, the school’s goal is vary from Richard’s individual goal which reduce the motivation and worsen the performance (Latham 2007). In order to reach the goal, James has to co-ordinate with other teachers with the class arrangement, this may lead to disagreement about the decision and conflicts between colleagues may result. With the new class arrangement, other classes need to adopt a new  teacher or teaching style; it influences the academic results and motivation. Others teachers also need to cope with the new goal and assi st Richard and principal in some points yet they do not get any reward, it leads to the problem of unfairness and inequality. Conclusion To conclude, goal and task are strongly linked and dimension of goal is divided into content and intensity. A successful goal should be set according to S.M.A.R.T. After evaluation, Richard is chosen as the teacher. James could motive Richard and students by financial and non financial rewards. Within the process, James has multiple roles as mention before to ensure the goal is achieved. However, unexpected results may happen therefore James should consider more theories application solve the problem and achieve synergy. Reference list Armstrong, M. and Murlis, H. 2007, Reward Management: A Handbook of Remuneration Strategy and Practice, 5th ed., Kogan Page Publishers, U.K. Bailey, K. 2006, Language Teacher Supervision: A case Based Approach, Cambridge University Press, U.K. Campbell, J., Kyriakides, L., Nuijis, D. and Robinson, W. 2012, Assessing Teacher Effectiveness: Different Models, Routledge, Canada. Latham, G. 2007, Work Motivation. History.Theory.Research and Practice, Thousand Oaks, U.K. Locke, E. 1996, ‘Motivation through conscious goal setting’, Applied and Preventative Psychology, vol.5, pp. 117-124. Locke, E. and Latham, G. 1990, A theory of Goal setting and Task Performance, Prentice Hall, New Jersey. Mitchell, D., Ortiz, F. and Mitchell, T. 1987, Work Orientation and Job Performance: The Cultural Basis of Teaching Rewards and Incentives, Suny Press, U.S.A. Robin, G. 2012, Praise, Motivation, and the Child, Routledge, U.S.A. Rouillard,L. 2003, Goals and Goal Setting: Achieving Measured Ob jectives, 3rd ed., Cengage Learning, U.S.A. Snell, S. and Bohlander,G. 2012, Managing Human Resources, Cengage Learning, U.S.A. Stronge, J. and Hindman, J. 2006, The Teacher Quality Index: A Protocol for Teacher Selection, ASCD, U.S.A. Quinn, R.E., Faerman,S.R., Thompson,M.P. and McGrath,M. 2003, Becoming a master manager: A competency framework, 3rd ed., Wiley, New York.

Question Outlines Essay Example

Question Outlines Essay Example Question Outlines Essay Question Outlines Essay Analyze the extent to which the Articles of Confederation were effective in solving the problems that confronted the new nation. Introduction: In America, between the years of 1777 and 1789, the Articles of Confederation served as the first constitution for the United States. This new document was the first attempt at a centralized national government, effective in solving few problems that arose in America. The articles successfully put an end to the Revolutionary War in 1783 with the Treaty of Paris. Two separate land ordinances were passed to settle the dispute over western lands under this indenture. Most importantly, it served as a superb example of what to change when drafting the U. S. Constitution. Therefore, the Articles of Confederation were effective in less than many ways. Topic Sentence 1: The Revolutionary war ended with the Treaty of Paris in 1783 under the Articles of Confederation. * Tired of being under Britain’s control, America rebelled against England and the Revolutionary war started. * The Treaty of Paris in 1783 officially ended the war with Britain allowing America to focus on the development of the country. Topic Sentence 2: Another issue solved while under the rule of the Articles consisted of the government establishing rules for northern land of America. * To prevent land ownership confusion, the land northwest of the Ohio River, east of the Mississippi River and south of the Great Lakes, commonly known as the Old Northwest, was divided into equal sections of land and sold to the public to pay for national debt. * This system of managing land was called the Land Ordinance of 1785. * The Northwest Ordinance of 1787 was made to further govern the Old Northwestern land. When a territory inhabited 60,000 people, the piece of land would be considered a state and no longer be own by the government. Topic Sentence 3: With the Articles Of Confederation solving few problems in America, the Constitutional Convention was organized to modify the Articles. * The members of the Constitutional Convention were authorized to only revise and edit the Articles of Confederation, but held secret meetings to completely rew rite a new constitution. * This new document gave the central government more needed power and addressed many of the issues the Articles did not. Conclusion: Although the Articles of Confederation only solved few issues in early America, the ones it did were necessary to the growth of the country. The Treaty of Paris in 1783 was the ending of the Revolutionary war. The Land Ordinance of 785, dealt with the dispute over the Old Northwestern land. The expansion and organization of the north was due to the Northwestern Ordinance of 1787. Lastly, the Articles of Confederation served as a stencil for the U. S. Constitution and as a starter for the strong centralized government we have today. McKenzie Sevier 11/16 Essay Outline #2 To what extent was the United States Constitution a radical departure from the Articles of Confederation? Introduction: After realizing the lack of power the Articles of Confederation had towards shaping a strong central government, the Constitutional Convention in 1787 was held to construct an all new organization for the U. S. government. That same year, the United States Constitution was ratified providing a better national government. The Articles of Confederation served as an important step in laying the foundation for the U. S. Constitution. Unlike the Articles, the Constitution better defined the relationship between the federal government and the states. The development of three branched of government were created to eliminate the chance of one branch gaining too much power. Thus, the strength and success of the national government under the U. S. Constitution, compared to the Articles of Confederation, was an extreme improvement for America. Topic Sentence 1: Under the Articles of Confederation, the relationship between state and government ruling was vague. The Confederation Congress had the power to make laws but uselessly could not enforce them. * The Articles stated that America could not conduct any form of foreign policy causing the military to be weak and ineffective. Topic Sentence 2: The U. S. Constitution was ratified in 1787 after the Articles of Confederation failed at forming a strong national government. * At the Constitutional Convention in 1787 the states’ representatives were t o review and revise the Articles. * The representatives arranged secret meetings to rewrite a whole new constitution, for fixing the old one seemed useless. This constitution was presented to the Congress of Confederation and after getting approval; the needed nine out of thirteen states ratified the U. S. Constitution. Topic Sentence 3: A structured from of government was created under the Constitution to better the development of America. * The Constitution consists of a preamble, seven original articles, twenty-seven amendments and a paragraph to certify its acceptance by the Constitutional Convention. * The seven original articles call for a three-branch government, the Judicial, Legislative, and Executive, creating a system of checks and balances to ensure the power is equally distributed. The first ten amendments are known as the Bill of Rights and were ratified simultaneously in 1791. Knowing change is bound to happen, the authors included in the articles state that new amendments could be added. Conclusion: Since the Articles of Confederation provided a weak government, the constitution was written drastically helping America’s government. The U. S. Constitution, compared to the Articles of Confederation, is a powerful, necessary guide for the development of America. The deviation fro m the Articles to the Constitution proved a drastic change in America’s national government. McKenzie Sevier 11/16 Essay Outline #3 To what extent did the American Revolution fundamentally change American society? In your answer, be sure to address the political, social, and economic effects of the Revolution in the period from 1775 to 1800. Introduction: In 1775 a war between Britain and America broke loose after the overbearing British soldiers overstayed their welcome in America. A troop of British soldiers collided with a troop of American soldiers in Concord, Massachusetts causing a conflict that soon grew out of control. The shot heard around the world† was the beginning of the American Revolution. This war caused many changes amongst American society including the freedom of America, the people believing in the equality of all, and the respect for one’s hard work. Thus, the American Revolution made an effect on society in the political, social, and economic aspects of life. Topic Sentence 1: The freedom of America was the beginning of a democratic nation starting with the Declaration of Independence. * This letter of complaints to England broke the ties between America and England. America began a representative government to better involve the people with the decisions of the new nation. * Topic Sentence 2: The social change of America was mainly present in the attitudes of common people. * The belief of the equality for all overcame American’s beliefs about the way life should be. Topic Sentence 3: Before the American Revolution, one’s hard work was not appreciated and basically didn’t matter. After the American Revolution, the appreciation of hard work was respected and looked highly upon. Conclusion: The notably drastic changes after the American Revolution influenced a free more independent life. With the Declaration of Independence, the change of attitudes, and the appreciation of hard work, America was constantly improving. Therefore, the political, social and economic effects of the American Revolution were drastically better than before the idea of independence was common. McKenzie Sevier 11/16 Essay Outline #4 Historians have traditionally labeled the period after the War of 1812 the â€Å"Era of Good Feelings. † Evaluate the accuracy of this label, considering the emergence of nationalism and sectionalism. Use the documents and your knowledge of the period 1815-1823 to construct your answer. Introduction: The time period after the War of 1812, traditionally labeled the â€Å"Era of Good Feelings†, was ironically not a time of complete positivity. The idea of nationalism of America kept hope alive for independence while sectionalism kept the north and south on conflicting terms. Thus, the â€Å"Era of Good Feelings† was not completely good. Topic Sentence 1: Nationalism in America was considered when America broke all ties with Britain. * America was not under the rule of another country and longer * American’s began to have a sense of independence and were able to grow as a nation rather than a part of another nation. Topic Sentence 2: Sectionalism arose when the North and South began to disagree over the idea of slaves. * There was fear of the North’s population growing out of control. * The Missouri Crisis settled the dispute calling for Mississippi to remain a slave state in return for Maine to become a state. Conclusion: The â€Å"Era of Good Feelings† was in all not great. The idea of Nationalism kept a positive note on America where as sectionalism was a national dispute keeping the North and South in conflict with each other. Therefore, the time period after the War of 1812 was not an â€Å"Era of Good Feelings. †

A Guide for Writing a Descriptive Essay Example + 40 Topics

A Guide for Writing a Descriptive Essay Example + 40 Topics A descriptive piece of writing is your chance to offer the reader see the picture with his own eyes.   Working on a descriptive essay example, you are going to provide your target audience with the perception through 5 senses. If you manage to do this the best way, your paper will be evaluated highly. If not, you are likely to get a low grade. Some students consider this piece of writing an interesting task to do. Others think it is much more difficult than any other written assignment. Are there any reasons to think so? Almost every day, you describe things with the aim to help other people imagine what you are talking about. Sometimes, listening to your description, the person understands what you mean from the 1st time. There are situations when it is extremely difficult to draw pictures using words. DESCRIPTIVE ESSAY WRITTEN BY PROFESSIONALS Not everyone has an ability to describe things in a bright clear manner.   This doesn't mean that you should just give up! No, never! This guide on how to compose a descriptive essay example will help you to learn writing basics. Follow the most effective tips for completing a paper that will 100% stand out! The Best Descriptive Essay Topics Collection Before you get started with the descriptive essay example writing, you should take several steps. The 1st one will be the selection of a topic. Choosing from descriptive essay topics, be guided by the rule to give preference to the topic you are familiar with and feel passionate about. It is very important for any type of paper, especially for this piece of writing. How can you describe the person you have never seen, the event you haven't attended, the phenomenon you haven't heard about? It is obvious that only being familiar with the main features and distinctive characteristics of the object/subject of your description, you'll be able to provide readers with a clear picture of this thing. Do you experience difficulties with the topic selection? Check descriptive essay topics and choose the one that sounds best. 10 Descriptive Essay Topics for Grade 8 Pick the topic you find the most interesting one: The portrait of my mother My best friend and me: common features we have The bird I like the most The perfect day of my life My favorite author My first school teacher How do I see my family dream house? What is my perfect weekend? What does the forest look like in winter? What makes my room unique? 10 Topics for Descriptive Essays High School Check a topics collection aimed at high-school students: What do I like/dislike in my appearance? Whom do you consider beautiful among celebrities? Describe the most interesting dream you have seen How should the best cup of coffee taste? Describe the best present in your life Do you believe that pets look similar to their owners? Describe your pet My room and the room of my sister/brother My father's character The smartphone of my dream Innovative characteristics of Apple gadget. 10 Descriptive Essay Topics for Middle School Check the collection of easy topics ideas: Which season do you consider best for traveling? What was your impression unwrapping birthday gifts? My favorite holiday celebration What kind of clothing style do you prefer? Describe the most beautiful sunset you have seen Which feelings does a person have going somewhere by plane? The prettiest girl/boy in my class The portrait of my grandparents My favorite food The best day of my life so far 10 Descriptive Essay Topics for College Have a look at descriptive essay topics that can be used by students studying at a college below: The mountain lake description How do you imagine the most romantic wedding day? Describe the feelings of a person who has fallen in love The person I love the most What kind of rest do I like? The worst summer holidays in my life Describe any labor activity Describe the process of writing a letter to a friend How do you choose gifts for your friends? Describe the process of work (your dad is repairing his car in the garage) The Best Tips on How to Write a Descriptive Essay Have you chosen the best topic? It is high time to learn how to structure this kind of paper the correct way. This genre doesn't differ much from other papers. Like any other one, it starts with an introduction, followed by the main body, and finally, there is the conclusion. Sure that this genre has its own distinctive features you should take into account. Don't you learn how to write a descriptive essay on A-grade? Check helpful tips for crafting a worthy descriptive paper that will impress your teacher. Offer the reader plunge into the world of your sensations. If two people are given a task to describe the same thing, they will do this differently. Every person perceives the world and everything that happens through his/her own vision. Being assigned to write a paper describing something, you should use a great opportunity to show how you see this/that object/person/event using the bright language rich in literary devices, which play a significant role in the reflecting atmosphere. Make your paper vivid. The key to success is to sound expressive. Your task is to help readers see the whole picture reading your paper. Words can work miracles being not less bright than a photograph. Help the reader understand the work’s purpose. Any paper topic has its purpose. The writer’s task is to provide readers with a clear understanding of what it is. Convey information following the outline. Making an outline is a must if you want to create a good work. A detailed plan will help not to miss any detail. Following the correct structure, there are all chances to craft a valuable piece of writing. If you aren't good at writing essays according to the structure, you are welcome to check how to write essay parts. Step by step, create a description that will sound real. ORDER YOUR DESCRIPTIVE ESSAY NOW The Introduction of a Descriptive Essay: How to Get Started? Some students spend hours brainstorming ideas on how to get started. Are you one of them? If you don't understand how to write a descriptive essay intro, start with a life story from your personal experience able to engage the reader. Your story should touch all 5 senses. Choose which one to start with. For example, describing a wedding day, start with the description of the atmosphere, music, decoration, etc. Make the reader guess what celebration it is. Creating intrigue works effectively. How to Craft a Powerful Descriptive Essay Thesis? A thesis statement is an obligatory part of your work. The purpose of this sentence is to introduce the key topic idea. The thesis should be clear and concise. It should be one informative paragraph.   Ã‚  Focus on the major idea, exclude everything that doesn't matter writing about the purpose and the way you are going to reach the goal. Tips on How to Write a Conclusion for a Descriptive Essay The end of the work should include the writer’s standpoint and the main points’ brief summary. Conclude the paper not leaving readers with questions left. Make it powerful because it has been proven that the reader's memory is organized in a way that implies he/she remembers the last words better than the main body’s information. Wonder how to write a descriptive essay conclusion? Check the example! Descriptive Essay Examples: Check the Correct One Before Getting Started! Is this the first time you need to craft a description? Check descriptive essay examples for you to understand how to do this the best way. Have a look at the example below. â€Å" The Woman I've Seen Once† Every day we see a lot of strangers passing them by without paying attention but that woman in the red dress stood out from the crowd. She was extremely beautiful. She knew about this and even felt proud of being like a model from the fashion magazine. She has long black hair, big black eyes that it was possible to dive into them and get lost forever like in the ocean. However, on their surface, I noticed waves of sorrow. The woman was standing silently.   The entire nature of hers was ready to scream from pain. Her eyes were full of tears looking at me - those were tears of sadness mixed with happiness. I wanted to come to her to ask what had happened. Unfortunately, something prevented me from this. I turned back, understood that she had disappeared. I did my best to find her seeing her nowhere. It was so strange because it seemed that her perfume was left in that park forever. I smelled it - it seemed so familiar to the one my mom had. She died when I was five. I wanted to find her seeing her in everyone. I will never forget the woman who looked so similar to my mom because she had such a sad face. I think that there are no meetings, which take place by chance. I am sure, that one has been planned by someone. Who was she? This has remained a secret. This doesn't matter because her appearance gave me a chance to see the image of my mom once again and feel her love wherever she is now†. A Descriptive Essay Outline Sample Depending on what you are going to write about, your outline will differ. Describe a person's appearance, an event, a process, a natural phenomenon, a picture, etc. In each case, the outline’s content will differ while the main structural elements we have already discussed above will remain. Check the descriptive essay outline sample that you can use describing a person. I. Introduction: The overall impression The features you have noticed 1st II.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Main Body: The description of the face/body parameters The description of the clothes The behavior of the person III.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Conclusion: Does the character of the person suit the appearance? What kind of features helped to find out what kind of personality the person has? The personal observations Advice from an Expert on How to Write a Descriptive Essay Example Write your work only after checking successful descriptive essay examples. Keep in mind that to complete a good essay of this genre, you need to be very careful with details. Don't make a big mistake considering details not very important for the overall impression. If writing about the person, analyze both the appearance/character, find out what the face features, clothes can tell about the personality. Describing any person/animal/not alive object, remember that you should have a clear picture of the topic to impress the reader with your detailed story. Use senses to help the reader see, smell, taste, hear, touch what you are writing about. Prof. Mary K., online essay writer from EssayPro Our Professionals Craft the Perfect Essay Worth A+! Have checked the descriptive essay example being unsure you can write this type of work on A+? Our professionals with years of experience will give a helping hand! Share the topic/the teacher's guidelines and we will do our best to exceed his/her expectations. We have a team of reliable writers treating the process of crafting essays as an opportunity to realize their potential. Just contact us writing â€Å"Write my essay cheap†. You will be pleasantly surprised by affordable prices per page we offer our customers to pay for. Forget about sleepless nights/long working hours during the day! We are here to help 24/7! Our experts are always ready to offer necessary academic assistance with any kind of work, regardless of the difficulty level! Don't hesitate to use our services if getting a high score is of the utmost importance for you! We promise you'll never regret hiring one of our well-educated talented writers! Tell us your wish - we will tailor our service to your personal wants/needs!

Teen Drinking Essay Example | Topics and Well Written Essays - 750 words

Teen Drinking - Essay Example However, our society has not caught up with the evolution of the teenager. They are still viewed as members of our society who need to be constantly policed and told what to do and when. This is the situation that applies to the drinking laws in relation to American teenagers. The rest of the world though, have come to acknowledge that it is better to recognize that teenagers will drink alcohol due to exterior influences and, therefore, society must learn to adapt and ensure that they drink responsibly instead. That is the focus of the T.R. Reid essay â€Å"Let My Children Drink†, while Joseph Califano Jr. chooses to oppose the view of Reid in his own essay titled â€Å"Don't Make Teen Drinking Easier†. Although I see the point of Mr. Califano, I must agree with the benefits as described in Mr. Reid's essay. That is because teenage drinking does happen and it cannot be ignored. The three points that I will be raising in this paper are that: 1. Teenagers who know their p arents trust them to drink responsibly make for more mature adults. 2. Anything done illegally is more likely to draw teenagers to try the activity and go overboard in the process. Teens will also commit crimes regardless of being drunk or not. 3. Lowering the drinking age will make teenagers mature faster in terms of personal responsibility and logical thinking. The worst age that a human being can be stuck in would have to be the wild, wonderful, and sometimes wacky teenage years. It is during this time in a teenagers life that he learns to experiment and differentiate for ourselves what, as adults, shall be the right and wrong actions for him. This is the time when releasing the parental restraints slowly reaps its benefits most specially in terms of teenage drinking. As Mr. Reid put it so effectively in his essay (Reid): As a wandering Post correspondent, I have raised teenagers in three places: Tokyo, London and Colorado. No parent will be surprised to read that high school and college students had easy access to alcohol in all three places. In all three countries, kids sometimes got drunk. But overseas, they did their drinking at a bar, a concert or a party. There were adults -- and, often, police -- around to supervise. As a result, most teenagers learned to use alcohol socially and responsibly. And they didn't have to hide it from their parents. By allowing teenagers to drink in a supervised situation, they are forced to take responsibility for their actions stemming from alcohol consumption. The presence of adults and other persons of authority is a clear indication to them that they will be allowed to have fun but not go overboard about it. This is the kind of situation that directly appeals to teenagers. It is obvious that the lower drinking age works for the teens mentioned in Reid's article because they are given full responsibility for their actions. You choose to drink, you take responsibility for whatever happens if you get drunk. End of story. That is the kind of maturing life lesson that teenagers so badly need in their lives. It is probably a stand that, if presented to most underage teenagers in America today, they would gladly agree to in order to prove that they can actually be as responsible as their adult counterparts if not more. However, Mr. Califano strongly disagrees with Mr. Reid simply because he is overprotective and unable to trust that a teenager, when given the freedom to choose, will choose to do the right thing. His data that explains that (Califano); â€Å"British fifteen and sixteen year olds were more than twice as likely as Americans to binge drink (50% vs. 24%) and to have been intoxicated within the past thirty days (48% vs. 21%).†

The invitro effect of sildenafil citrate on the outcome of pregnancy Literature review

The invitro effect of sildenafil citrate on the outcome of pregnancy in mice and offsprings - Literature review Example Other medications that can be put to use to make infertile women conceive a baby includes the controlled ovarian stimulation, intrauterine insemination (IUI), and ovulation induction. Although the use of ART can result to a successful pregnancy, not all women who undergo ART can become pregnant. Infertility may occur in all types of species; whether human or animals. This chapter tries to investigate the expression of PDE5 in the pre-implantation embryos and the effect of sildenafil citrate (Viagra) on pre-implantation murine embryo development in vitro. Sildenafil is a special drug with a nitric oxide effects on vascular smooth muscles. Randomly selected mice were divided into two groups. One group was hyper stimulated group whereas the other was hyper stimulated plus sildenafil citrate group. The mice were injected with human menopausal gonadotropin (HMG), and later they received human chorionic gonadotropic (HCG) hormones. Afterwards, two female mice were put in one cage with one male mouse for mating process (Rashidi, Rad, Roshangar, & Mira, 2012). For a period of three days, the hyper stimulated plus sildenafil citrate group was injected with three mg of sildenafil citrate after every 24 hours. This was done after the mice had received the HMG injection. Ninety six hours of HMG injection later a cervical dislocation was done, and their urine specimens were prepared for laboratory tests; electron microscope studies. After the study, it was realized that there was long and short microvilli in the control group while no observable pinopodes development. On the other hand, the other hyper stimulated plus sildenafil citrate group experienced pinopodes development after injecting the mice with HMG after four days. This study brings to the attention on how import hyper stimulation of mice with sildenafil citrate can be. For instance, it helps in formation of pinopodes and implantation. Failure of implantation is one of the major problems in infertility treatment. In addition, implantation is believed to be one of the most interesting biological events. Implantation failure can be as a result of impaired uterine receptivity caused by high concentration of serum estradiol, which is induced by an ovulation induction treatment. Appearance of pinopodes is a specific morphological marker that has been associated with window of implantation (Rashidi, Rad, Roshangar, & Mira, 2012). The pinopodes are found in mice and rats but lack in other animals and humans. These are surface projections of the endometrial cell, which are involved in uterine pinocytosis. These pinopodes are essential in the implantation window, and for this reason, it is of note for them to be developed in mice at-time to facilitate implantation. The use of sildenafil citrate can maintain effectively the vasodilatory effects of the Nitrogen Oxide by blocking the breakdown of cGMP. Reducing the problems associated with the development of a foetus is possible through proper facilita tion of blood to the endometrial lining. In addition, enhancing the flow of blood to the endometrium lining will help reduce the risk of maternal hemodynamic complications. Also known as Viagra TM or RevatioTM,

Land Law solve the problem with Sunnydale Cottage Essay

Land Law solve the problem with Sunnydale Cottage - Essay Example †¢In May 2006, Charlotte went abroad for a few months on holiday. She sent post cards to each of the other inhabitants of Sunnydale Cottage saying that she had met Costas, a Greek waiter, and wanted to marry him. Accordingly, she notified them all that â€Å"My one fifth share in Sunnydale Cottage is to be ring-fenced and should anything happen to me Costas is to get it.† The postcard to Barbara was lost in the post and never delivered. Charlotte has tried of Costas and has now returned to live in Sunnydale Cottage. The TLATA avoids this problem as there is no duty to sell under a trust of land, merely a power of sale. All land subject to a trust will be held on a "trust of land" (TLATA s 1). Existing settlements are excluded, but land already held on express or implied trusts for sale are included within the provision. Although it is still possible to create express trusts for sale, as a subset of the trust of land, this will rarely be appropriate for domestic situations, and even here the power to postpone sale cannot be excluded. This means that there is no longer a problem posed by an imperative duty to sell, in situations where that was the last thing intended. One of the most important features of the TLATA is the nature of the trust of land. No longer is there a duty on the trustees to sell the land, there is simply a power to do so if desired. This perhaps reflects the fact that the reasons why trusts are set up nowadays are not the same as in 1925. The trustees of land, when exercising any function relating to the land subject of the trust, are now under a duty (as far as practicable) to consult with beneficiaries of full age and beneficially entitled to an interest in possession in the land. They must give effect to the wishes of those beneficiaries, so far as they are consistent with the general interest of the trust. If there is a dispute among the

Tuberculosis: Prevention and Treatment

Tuberculosis: Prevention and Treatment Tuberculosis (TB) is an airborne infectious disease which is caused by strains of mycobacteria, mainly Mycobacterium tuberculosis1. There are roughly one third of the worlds population are infected with tuberculosis where nine millions of new cases reported annually2. Although tuberculosis can be prevented and treated, it continues to cause millions of deaths every year2. When infected individual coughs, sneezes or spits, M. tuberculosis is propelled into the air and infected those who breathed in the bacteria that existed in droplets of saliva3. Primarily, tuberculosis will affect the lungs, known as pulmonary tuberculosis3. It will also affect other parts of body, for instance lymph nodes, bones, brain and kidneys3. Once a person is infected with tuberculosis, there are basically three possible ways may occur. Firstly, the immune system plays a vital role and strong enough to kill the bacteria3. Secondly, immune system is not strong enough to fight off the bacteria but is able to b uild a defensive barrier against the bacteria3. Individuals who are latently infected with M. tuberculosis show asymptomatic where these bacteria lie dormant in the lungs and able to reactivate after years1. The disease is often reactivated in those who are immunocompromised or generally weakened. Lastly, the immune system fails to kill bacteria causing the bacteria to grow and spread towards other parts of body which is called active tuberculosis3. In the fight of tuberculosis, World Health Organisation (WHO) recommends universal Bacille Calmette-Guà ©rin (BCG) vaccination in the countries with high TB burdens4. BCG vaccine contains weakened form of M. tuberculosis which will induce human antibodies to fight against this type of bacteria. The efficacy of BCG vaccination can be ranging from 0% to 84%5. This may be due to the frequency of TB exposure and quality of vaccine used, leading to arguments on BCG vaccination efficacies4. One of the greatest arguments is that BCG vaccination causing positive reactions to tuberculin skin testing and hence interfere with the diagnosis of latent TB4. Existence of evidences showing the rates of efficacy also depends on geographical location, age at vaccination and form of TB further complicate the situation. Currently, TB chemotherapy is made up of combination of a list of first-line drugs isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB) 6. If the treatment fails d ue to bacterial drug resistance, or patient unable to tolerate, second-line drugs for instance para-aminosalicylate (PAS), fluoroquinolones, ethionamide and cycloserine are introduced6. These are considered as second line drugs generally either less potent with larger doses regimen or more toxic with serious side effects6. Tuberculosis is presently treated in two phases, namely initial phase and continuous phase7. In initial phase, the patient will be treated with concurrent use of four first line drugs, with the aim to eradicate or control bacteria population to replicate in rapid motion and also avoid the emergence of bacteria resistance7. The treatment choices available for initial treatment include isoniazid, rifampicin, pyrazinamide and ethambutol7. Streptomycin is used rarely but can be used in patients who infected with bacteria that are resistant to isoniazid before the therapy is commenced7. The duration for initial phase is 2 months whereas the continuous phase takes 4 months7. During the four months of continuous phase, patients are treated with isoniazid and rifampicin at same doses7. Most of the TB treatment is supervised where drug administration needs to be fully supervised by healthcare professions since lengthy duration of treatment causing incompliance in patients7. These patients who are unlikely to be compliance will be given the drugs three times a week until the course is completed while patients who able to comply with the treatment will not be supervised7. Despite the chemotherapy treatment and BCG vaccine, TB remains as a significant infectious disease due to increasing emergence of drug resistant TB and co-infection with Human Immunodeficiency Virus (HIV) 6. Since the host defense in HIV patients is suppressed, they are more susceptible to TB infections. Moreover, drug- drug interactions between antiviral therapy and anti-TB also causing complications in treating co-infected patients6. Drug resistant TB has evolved mainly because of improper treatment or incompliance in patients who stop taking their medications before the bacteria is being fully eradicated since the duration of treatment is lengthy which takes 6-9 months8, 9. The mechanism involved includes chromosomal mutations in genes that responsible for drug targets encoding9. When there is a sequential accumulation of mutations, multi-drug resistant tuberculosis (MDR-TB) emerges where the M. tuberculosis strains will resistant to two of the most commonly used drugs, Isoniazid and Rifampicin9. Patients with MDR-TB are then relying on the second-line drug classes, fluoroquinolones and the three injectable agents namely amikacin, capreomycin, and kanamycin10, 11. The chances to cure would dramatically be reduced for patients who infected with extensively drug-resistant tuberculosis (XDR-TB), a situation where the isolated strains are resistant against any one of fluoroquinolones and at least one of three injectable drugs6. In order to combat with the MDR-TB or XDR-TB and optimize the tuberculosis drug regimen, it is crucial to understand the mechanism of action of current using first-line drugs and how resistance is developed against these drugs. Isoniazid (INH) or isonicotinic acid hydrazide is discovered in 1952, a bactericidal agent which active against organism of the genus Mycobacterium, especially M. tuberculosis, M. bovis and M. kansassi6, 12. In vivo, INH has shown to be bactericidal in culture over the first 48 hours which become bacteriostatic after this particular time frame12. This indicates that INH is bacteriostatic for slow replicating bacilli but is bactericidal against rapidly dividing mycobacterium. The minimal tuberculostatic concentration is 0.025 to 0.05ug/ml13. INH is a prodrug that needs to be activated by catalaseperoxide hemoporotein, KatG before acts by inhibiting mycolic acid synthesis and cell wall disruption in susceptible mycobacterium13, 14. This inhibitory action is only targeted to mycobacteria since other bacteria do not contain mycolic acid in the cell wall13. INH acts by inhibit enoyl acyl carrier protein (ACP) reductase, InhA, and a beta-ketoacyl-ACP synthase, KasA that are crucial in fatt y acid synthesis system for mycolic acid15. Resistance to INH is believed due to mutations in gene encoding catalaseperoxidase katG or InhA or lacking KatG 9, 14. Isoniazid is metabolised in the liver, mainly by acetylation and dehydrazination where slow acetylator may experience higher concentration leads to potential toxicity before excreted in the urine within 24 hours13. Rifampicin (RIF), discovered in 1963, is a lipophilic semisynthetic derivative of rifamycin antibiotic which is produced by the fermentation of a strain of Amycolatopsis mediterranei6, 9, 16. RIF has bactericidal activities against a broad spectrum of microorganisms including gram-positive and gram-negative. RIF will inhibit the action of DNA-dependent RNA polymerase of mycobacteria that is encoded by rpoB through formation of a stable drug-enzyme complex9. This will suppress the initiation chain formation in RNA synthesis and hence prohibit protein synthesis in M. tuberculosis9. Development of resistance to RIF is mostly due to mutation in 81 base pair region of rpoB gene thus facilitate a straightforward approach to detect MDR-TB since 85-90% RIF-resistant strains are also resistant to INH9. RIF produces peak plasma concentration of 7ug/mL in 2 to 4 hours after ingestion of 600mg17. It also distributed well to most of the body tissues and fluids, including cerebrospinal fluid since it is lipophilic17. Following absorption from the gastrointestinal tract, RIF is eliminated rapidly in the bile with fewer amounts excreted through urine17. Pyrazinamde (PZA) is discovered in 1954 and it produces excellent sterility effects against semidormant tubercle bacilli at slightly acidic pH6, 9. The antimicrobial activity of PZA is through interference with mycolic acid synthesis in M. tuberculosis by pyrazinoic acid, an active moiety of PZA9. Conversion of PZA to pyrazinoic acid is mediated by pyrazinamidase enzyme that is encoded by pncA gene in M. tuberculosis, thus indicating that these bacilli are sensitive to PZA9. Resistance against PZA evolved when mutation occur at pncA gene that is responsible for pyrazinamidase, hence affecting the activity of this enzyme9. PZA is well absorbed from gastrointestinal tract and is widely distributed to most tissues and fluid too17. The oral administration of 500 mg PZA produces plasma concentrations of 9-12ug/ml after two hours and 7ug/ml after 8 hours17. PZA is metabolized in liver whereas the metabolites are excreted through renal glomerular filtration17. Ethambutol (EMB) is discovered in 1962, acts as bacteriostatic agent and is active against undergoing cell division6, 18. EMB primarily targets on impairment of cell wall polymerization by inhibits arabinosy transferase, a vital enzyme responsible for mycobacteria cell wall biosynthesis9, 18. Since arabinosy transferase enzyme is encoded by embC-embA-embB genes, resistance against EMB evolved is believed due to mutation of these genes9. EMB is currently used as one of the first-line treatment for tuberculosis mainly because of its synergistic effect with other front-line drugs and its low toxicity property18. There is roughly 75-80% of an oral dose of EMB is rapidly absorbed in gastrointestinal tract with absorption unaffected when administered with foods19. In addition, EMB is distributed widely to body tissues and fluid, including cerebrospinal fluid before being metabolized in the liver and excreted in urine19. Streptomycin (SM) is an aminoglycoside antibiotic, used as first line treatment for TB when it first discovered in 19441, 6. Streptomycin is isolated from the bacteria Streptomyces griseus and its antimicrobial effects against M. tuberculosis is highly effective when use in combination with other first line agents20. However, SM is no longer considered as first line treatment as resistance against it has developed rapidly1. The optimum pH for SM is at pH8 where its bacteriostatic activity will reduce with increasingly acidic environment20. SM acts by binding tightly to A site of 16S ribosomal RNA subunit, interferes with mRNA translation, causing faulty protein being produced1, 9. Resistant emergence when the mutation occurs at gene rpsL and rrs that encoded for 16S and S12 ribosomal protein1, 9. Upon administration, SM is poorly absorbed from gastrointestinal tract and mostly administered parentally1. SM is mostly excreted in urine and patients with low renal profile might experienc e toxicity such as neurotoxic reactions1. When the first line treatment is no longer suitable for patients or patients develop multi-drug resistance TB, second line drugs will then be introduced in combating the TB. Second line drugs that are mostly used include Ethionamide (ETH), Cycloserine (CS), Para-Aminosalicylic Acid (PAS) and Fluoroquinolones (FQ). ETH has been in use since 1960s, is a structural analogue of INH and it targets at inhibition of mycolic acid biosynthesis in tubercle bacilli9, 21. INH however is much more potent than ETH since the minimal inhibitory concentration for ETH is 0.5-5.0ug/mL21. Resistance evolved due to mutation at gene InhA and ethA which encode for oxygenase enzyme in activation of ETH 9. In vitro, CS has inhibitory effect on M. tuberculosis at 5-200ug/mL and there is no cross resistance occurred between CS and other drugs13. CS acts by interfereing the biosynthesis of bacterial cell wall13. CS is well absorbed in gastrointestinal tract and also widely distributed to body tissues and fluid including cerebrospinal fluid13. PAS was first introduced as first line drug but being replaced by Ethambutol in 1960s1. It acts bacteriostatically with possessing inhibitory effect at concentration less than 1mg/ml by interfere with folic acid metabolism in bacteria1. PAS is readily absorbed from gastrointestinal tract and distributed well throughout the body. Approximately 80% of the drugs will be excreted via kidney after being metabolized to acetylated form1. Moxifloxacin and Gatifloxacin are both been synthesized and evaluated as excellent bactericidal agents through inhibiting DNA gyrase, an ATP-dependent enzymes topoisomerase II which is responsible in bacteria DNA transcription9. DNA gyrase is consisted of two subunits that is arranged in a complex, is encoded by two different genes, gyrA and gyrB where mutations at gyrA will normally cause bacteria resistance to these new generation of flouroquinolones9. Due to the increasing incidence of multidrug resistance TB, it is highly desirable to develop new drugs that are not only potent and effective against current resistant strains of M. tuberculosis but also possess shorter treatment duration since most of the incompliance of patients is brought up by lengthy TB treatment. Most of the mechanisms of action of current treatments are involved in interfering the bacterial DNA synthesis, protein and mycolic cell wall biosynthesis. The enzymes that participate in these pathways could also be the target of newly designed drugs such as TMC207, one of the new drugs which are currently under investigations and clinical trials. TMC207 is a member of diarylquinoline class of compound which target at adenosine triphosphate (ATP) synthase by binding to subunit C of the synthase, blocking the energy pathway of mycobacteria22, 23. In vitro, TMC207 not only possesses ability to inhibit both drug sensitive and resistant M. tuberculosis isolates, but also able to sterilize the patient through killing the dormant bacilli bactericidally22. TMC207 showed a minimum inhibitory concentration of 0.03ug/mL against M. tuberculosis, suggesting a more potent agent compared to current first- line treatments such as isoniazid and rifampicin23. Apart from that, its synergistic effect with pyrazinamide could promise as effective drug combination for sterilizing the patients against TB22. A phase I clinical trials which involved short terms administration of TMC207 in healthy individuals showing no adverse effects and the subjects are well tolerated with it23. However, it is essential to investigate the selectivity of TMC207 again st mammalian ATP synthase with longer periods to ensure the patients safety when administered with TMC207. Thiacetazone (TAC) is widely used as second line anti-TB agent against multiresistant tuberculosis at present24. TAC acts by interferes the biosynthesis pathway of mycolic acid in tubercle bacilli24. The fact that M. tuberculosis has been difficult to eradicate and remains persistent is due to its cell wall that composed of mycolic acid which is resistant against chemical injury, dehydration and also has low permeability to antibiotics24. Mycolic acid contains cyclopropane rings that is activated through cyclopropane mycolic acid synthase (CMASs), has a significant contribution to tuberculosis24. By inhibiting the cyclopropanation, the cell wall biosynthesis will then be interrupted, introducing the bactericidal effects24. The aim of this research is to synthesis and evaluates the analogues of Thiacetazone which might be potential anti tuberculosis agents. The analogues will be tested against different strains of mycobacteria in lab. The target actions of these analogues will also be identified based on the structure of the analogues. The above analogue is synthesized when a benzylaldehyde reacts with a primary amine. This is a condensation process and an imine is produced. The changes at position R1 to R3 with different electron withdrawing groups are first planned to be evaluated. However, the plan is prohibited since the corresponding structures are either unavailable or too expensive that falling outside the budget. After revised on the previous analogues that were discovered and their respective MIC values obtained from lab, the structures of new analogues that are going to be evaluated are finally sorted out. The R1 to R3 positions would be replaced by either a -chloro or a -methoxy with R8 position would either be an amine, a methyl or a benzene ring. A chloro is used at position R1 to R3 since it is electron withdrawing, big and lipophilic molecule whereas the methoxy group is electron donating, small and quite lipophilic. For R8 position, an amine is selected because it is electron withdrawing and small. A methyl is also selected since it is quite lipophilic, small and electron donating. On the other hand, benzene ring which is highly lipophilic, neither electron donating nor withdrawing group might have a different effect on the analogue synthesized. References: Patrick Brennan, Douglas Young (2008). Tuberculosis. 88(2), 85-86, 137-138, 162-163. Health Protection Agency. http://www.hpa.org.uk/HPA/ National Health Services. http://www.nhs.uk/Pages/HomePage.aspx Zaida Araujoa, Jacobus Henri de Waard, Carlos Fernà ¡ndez de Larrea, Rafael Borges, Jacinto Convit (2008). The effect of Bacille Calmette-Guà ©rin vaccine on tuberculin reactivity in indigenous children from communities with high prevalence of tuberculosis. Vaccine 26, 5575-5581. Hart and Sutherland (1977). BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life. Br Med J2(6082), 293-295. Global Alliance for TB Drug Development. http://www.tballiance.org/home/home.php 57th edition of British National Formulary: Section on Tuberculosis drugs, 316-317. Blumberg, H. M. et al. (2003). American Thoracic Society/ Centers for Disease and Prevention/ Infectious Disease Society of American: treatment of TB. Am.J.Respir.CareMed.167, 603-662. Suhail Ahmad and Eiman Mokaddas (2009). Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis. Respiratory Medicine 103(12), 1777-1790. Frieden TR, Sherman LF, Maw KL, et al. (1996). A multi-institutional outbreak of highly drug-resistant tuberculosis: epidemiology and clinical outcomes. JAMA 276, 1229-1235. Mukherjee JS, Rich ML, Socci AR, et al. (2004). Program and principles in treatment od multi-drug resistant tuberculosis. 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Streptomycin: Background, Isolation, Properties and Utilisation. Science, 118(3062), 259-266. Sampson AE, Barry CE (1999). Abstract General Meeting American Society Microbiology. 99, 635. Andreas H.D., Alexander Pym, Martin Grobusch et al. (2009). The Diarylquinoline TMC207 for Multidrug- Resistant Tuberculosis. 360(23), 2397-2405. Anna C. Haagsma, Rooda Abdillahi-Ibrahim, Marijke J. Wagner, Klaas Krab, Karen Vergauwen, Jerome Guillemont, Koen Andries, Holger Lill, Anil Koul, and Dirk Bald (2009). Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towardsthe Eukaryotic homologue. Antimicrobial Agents and Chemotherapy, 53(3), 1290-1292. Anuradha Alahari, Xavier Trivelli, Yann Guà ©rardel, Lynn G. Dover, Gurdyal S. Besra, James C. Sacchettini, Robert C. Reynolds, Geoffrey D. Coxon, Laurent Kremer (2007). Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in mycobacteria. PloS ONE, 2(12): e1343. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall. Pathogenic mycobacteria carry mycolic acid sub-types that contain cyclopropane rings. Double bonds at specific sites on mycolic acid precursors are modified by the action of cyclopropane mycolic acid synthases (CMASs). The latter belong to a family of S-adenosyl-methionine-dependent methyl transferases, of which several have been well studied in Mycobacterium tuberculosis, namely, MmaA1 through A4, PcaA and CmaA2. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence of M. tuberculosis. While several antitubercular agents inhibit mycolic acid synthesis, to date, the CMASs have not been shown to be drug targets. We have employed various complementary approaches to show that the antitubercular drug, thiacetazone (TAC), and its chemical analogues, inhibit mycolic acid cyclopropanation. Dramatic changes in the content and ratio of mycolic acids in the vaccine strain Mycobacterium bovis BCG, as well as in the related pathogenic species Mycobacterium marinum were observed after treatment with the drugs. Combination of thin layer chromatography, mass spectrometry and Nuclear Magnetic Resonance (NMR) analyses of mycolic acids purified from drug-treated mycobacteria showed a significant loss of cyclopropanation in both the ?- and oxygenated mycolate sub-types. Additionally, High-Resolution Magic Angle Spinning (HR-MAS) NMR analyses on whole cells was used to detect cell wall-associated mycolates and to quantify the cyclopropanation status of the cell envelope. Further, overexpression of cmaA2, mmaA2 or pcaA in mycobacteria partially reversed the effects of TAC and its analogue on mycolic acid cyclop ropanation, suggesting that the drugs act directly on CMASs. This is a first report on the mechanism of action of TAC, demonstrating the CMASs as its cellular targets in mycobacteria. The implications of this study may be important for the design of alternative strategies for tuberculosis treatment.